One of Arizona’s most prolific entrepreneurs, Jason Hope, has long been deeply interested in the ability of medicine to extend the lifespan of the average American. Over the course of the last 50 years, Hope notes that the average American lifespan has increase by more than 15 years, marking a tectonic shift in the ability of people to live longer than ever.
It has been due to this intense interest in the ability to potentially increase longevity by significant margins that Hope has long been one of the most important philanthropists in medicine throughout the state of Arizona. Recently, Hope donated more than half a million dollars to the SENS Foundation, one of the most prestigious private research institutions in the United States today.
Hope says that the money will go directly to atherosclerosis research. This is a crucial area of research due to the fact that atherosclerosis is the root cause of up to 50 percent of all deaths in the United States caused by disease. Atherosclerosis is the causal mechanism in diseases ranging from heart attack and stroke to mesenteric ischemia and even aortic dissection. This makes the disease one of the most dangerous and deadly conditions known to man.
But Hope also sees the ability to kill two birds with one stone through his donations. Through his intense study of the medical literature, Hope has concluded that it will be possible to apply knowledge gained from the treatment of atherosclerosis to many other diseases of the aging process. This is because the same biological processes involved in the formation of atheroslcerotic plaque are also involved in nearly every major disease process that takes place in the geriatric population.
Atherosclerosis is primarily a product of tiny insults to the walls of blood vessels. This is then followed by an acute inflammatory process that eventually results in a fibrous cap being placed over the top of inflammatory debris, such as red blood cells and other proteins involved in the repair of damaged tissues. Over time, this inflammatory response eventually results in scar tissue, leaving the vessel walls weakened and unable to carry out their normal pulsating rhythms that allows for the normal flow of blood.
Eventually, in the case of coronary arteries and those involved in the brain area, this can lead to either vessel rupture or complete occlusion of the blood vessel, leading to strokes, heart attacks and cerebral hemorrhaging. However, almost an identical process is believed to be the root cause of diseases ranging from glaucoma to rheumatoid arthritis and even wrinkly skin.
Hope believes that through research into the atherosclerotic process, it will eventually be possible to create a real-world Fountain of Youth.